Mar. Drugs, Volume 16, Issue 10 (October 2018) – 55 articles
The RP1, was considerably more active than SP1 against the planktonic and biofilm growth forms of S. aureus ATCC 25923 and P. aeruginosa ATCC 15442. The results with molecular dynamics (MD) simulations obtained point out that RP1 shows a remarkable preference for bacterial membranes, in agreement with the antibacterial activity in vitro. Our results lay the foundation for the development of novel AMPs using RP1 scaffold as a potential and effective template. View this paper.
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