Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
Results and Discussion
Oxidation of Pellynol A (5) with MnO2: Conversion to 1
- Sample Availability: Samples are available from the authors.
References and Notes
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- Compounds 23 and 4 were not tested against HCT-116 due to insufficient material or decomposition.
- None of the compounds showed significant antifungal activity (Candida glabrata) in their pure states.
- This is surprising as other compounds in this class, such as 3–9 exhibit cytotoxicity to mammalian cells.
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- Compounds were assayed with compounds in DMSO (final concentration, 1% v/v) and run against etoposide as positive control. HCT-116 cells were incubated in 96-well plates for 72 h before addition of MTS. Well absorbances (λ 490 nm) were corrected for background and expressed as a percentage of the negative control (DMSO, only).
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Zhou, G.-X.; Molinski, T.F. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Mar. Drugs 2003, 1, 46-53. https://doi.org/10.3390/md101046
Zhou G-X, Molinski TF. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Marine Drugs. 2003; 1(1):46-53. https://doi.org/10.3390/md101046Chicago/Turabian Style
Zhou, Guang-Xiong, and Tadeusz F. Molinski. 2003. "Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity" Marine Drugs 1, no. 1: 46-53. https://doi.org/10.3390/md101046