Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
Abstract
:1. Introduction
2. NRF2 Structure and Regulation
2.1. NRF2 Discovery
2.2. NFE2L Family Members
2.3. NRF2 Structure
2.4. Canonical Regulation of NRF2
3. Cellular Functions of NRF2
3.1. Antioxidant Defence: The Canonical NRF2 Function
3.2. Iron Homeostasis
3.3. Inflammation
3.4. Mitochondrial Biogenesis
4. NRF2 during the Progression of Cardiovascular Diseases
4.1. Hypertension
4.2. Heart Failure
4.3. Atherosclerosis
4.4. NRF2 Contribution to Cardiac Dysfunction
5. NRF2 in Ageing-Associated Cardiovascular Diseases
5.1. In Vivo Models of Ageing
5.2. NRF2 Signalling during Human Ageing
5.3. Cardiovascular Diseases and Ageing
6. Drug-Induced Cardiotoxicity and the Role of NRF2
6.1. Pathophysiology of Doxorubicin-Induced Cardiotoxicity and Antitumour Activity
6.2. Doxorubicin Cardiotoxicity and NRF2 Pathway Interplay
7. Oncological Roles of NRF2
7.1. Somatic Mutations within NRF2 Regulation
7.2. NRF2 Signalling in Cancer
7.3. Pharmacological Manipulation of NRF2 Signalling in Cancer Therapy
8. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Roberts, J.A.; Rainbow, R.D.; Sharma, P. Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling. Int. J. Mol. Sci. 2023, 24, 6723. https://doi.org/10.3390/ijms24076723
Roberts JA, Rainbow RD, Sharma P. Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling. International Journal of Molecular Sciences. 2023; 24(7):6723. https://doi.org/10.3390/ijms24076723
Chicago/Turabian StyleRoberts, James A., Richard D. Rainbow, and Parveen Sharma. 2023. "Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling" International Journal of Molecular Sciences 24, no. 7: 6723. https://doi.org/10.3390/ijms24076723