Next Article in Journal
Evaluation of the Selected Mechanical and Aesthetic Properties of Experimental Resin Dental Composites Containing 1-phenyl-1,2 Propanedione or Phenylbis(2,4,6-trimethylbenzoyl)-phosphine Oxide as a Photoinitiator
Next Article in Special Issue
Epoxide Hydrolases: Multipotential Biocatalysts
Previous Article in Journal
Intensity Ratio of / in Selected Elements from Mg to Cu, and the Chemical Effects of Cr 1,2 Diagram Lines and Cr / Intensity Ratio in Cr Compounds
Previous Article in Special Issue
Synthesis and Characterization of Aminoamidine-Based Polyacrylonitrile Fibers for Lipase Immobilization with Effective Reusability and Storage Stability
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Editorial

Biocatalysis and Bioactive Molecules: Future and Development

1
Department of Bioprocesses and Biotechnology Engineering, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 4800-903, SP, Brazil
2
Department of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(6), 5571; https://doi.org/10.3390/ijms24065571
Submission received: 22 February 2023 / Revised: 7 March 2023 / Accepted: 10 March 2023 / Published: 14 March 2023
(This article belongs to the Special Issue Biocatalysis and Bioactive Molecules: Future and Development)
Due to the increasing interest in molecules obtained by bioprocesses over the past decade, biocatalysis has gained momentum in a variety of industrial sectors. Molecules obtained by enzymatic synthesis are high-added-value products recognized as natural agents. In addition, enzymatic reactions allow reductions in waste generation, thereby promoting sustainable development. However, to consolidate the use of these biocatalysts in industry, efforts are still necessary to develop biocatalysts with high stability, longer half-life time, and lower economic impact.
Currently, relevant topics within the biocatalysis field include directed evolution to improve the properties of enzymes, enzymes to perform new-to-nature reactions, and the development of green processes and technologies, mainly through valuing renewable resources.
Enzyme-improvement strategies that yield biocatalysts with better properties include the search for new methods/supports for enzyme immobilization and the use of protein engineering. When well designed, immobilization can be a very powerful tool to improve enzyme stability and widen the applicability of enzymes in industrial settings [1]. For this, the careful selection of the immobilization method and carrier matrix has fundamental importance. Through protein-engineering techniques, it is possible to alter enzyme properties, improve reaction performance metrics, and expand the application of biocatalysts to new reactions.
The needs that will define the future of biocatalysis include new types of enzyme-catalyzed reactions, the development of cost-effective enzyme synthesis routes to expand the use of enzymes in bioprocesses, and the search for enzymes with additional abilities, such as catalytically promiscuous ones that can expand the catalytic action to new reactions.
Biologically active molecules are natural compounds of particular interest to the pharmaceutical, food, and dermo-cosmetic industries. These molecules are usually chiral compounds produced by living organisms as single stereoisomers that cannot be artificially obtained. From this perspective, biocatalysis offers a broad range of easily accessible enzymes to perform challenging reactions with excellent results in terms of yield and selectivity [2]. Biocatalytically produced bioactive molecules can improve quality of life as they are environmentally friendly and also have beneficial impacts on the health of the human body in the prevention and treatment of various chronic diseases.
To achieve real progress in sustainability, a more circular production from renewable biomass is necessary. The use of alternative substrates in bioprocesses, such as agro-industrial waste, complements circular economy principles. Furthermore, to guarantee the development of green processes, other aspects must be observed, such as the use of biosolvents for the recovery and purification of biocompounds. Finally, high-quality environmental and economic assessments are increasingly seen as fundamental in evaluating the impacts of implementing new cost-effective processes.
Papers regarding biocatalysis and the bioactive molecules field are welcomed for submission to the current Special Issue entitled “Biocatalysis and Bioactive Molecules: Future and Development” to analyze and discuss processes aimed at the development of more sustainable synthesis routes.

Author Contributions

Conceptualization, methodology, investigation, writing—preparation of the original draft, writing—proofreading and editing, visualization and supervision were carried out equally between D.R. and L.A.L. All authors have read and agreed to the published version of the manuscript.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Remonatto, D.; Miotti, R.H.; Monti, R.; Bassan, J.C.; de Paula, A.V. Applications of Immobilized Lipases in Enzymatic Reactors: A Review. Process Biochem. 2022, 114, 1–20. [Google Scholar] [CrossRef]
  2. Presini, F.; di Carmine, G.; Giovannini, P.P.; Cristofori, V.; Lerin, L.A.; Bortolini, O.; Trapella, C.; Fantinati, A. Chemoenzymatic Stereodivergent Synthesis of All the Possible Stereoisomers of the 2,3-Dimethylglyceric Acid Ethyl Ester. Catalysts 2021, 11, 1440. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Remonatto, D.; Lerin, L.A. Biocatalysis and Bioactive Molecules: Future and Development. Int. J. Mol. Sci. 2023, 24, 5571. https://doi.org/10.3390/ijms24065571

AMA Style

Remonatto D, Lerin LA. Biocatalysis and Bioactive Molecules: Future and Development. International Journal of Molecular Sciences. 2023; 24(6):5571. https://doi.org/10.3390/ijms24065571

Chicago/Turabian Style

Remonatto, Daniela, and Lindomar Alberto Lerin. 2023. "Biocatalysis and Bioactive Molecules: Future and Development" International Journal of Molecular Sciences 24, no. 6: 5571. https://doi.org/10.3390/ijms24065571

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop