Molecules

255 KiB

Open AccessArticle

Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

by Jie Shi, Mei-Yu Geng and Chang-Xiao Liu

Molecules 2004, 9(11), 978-987; https://doi.org/10.3390/91100978 - 30 Nov 2004

Cited by 4 | Viewed by 7715

Abstract

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have [...] Read more.

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs. Full article

► Show Figures

Figure 1

231 KiB

Open AccessArticle

Preparation of Poly(oxybutyleneoxymaleoyl) Catalyzed by a Proton Exchanged Montmorillonite Clay

by Mohammed Issam Ferrahi and Mohammed Belbachir

Molecules 2004, 9(11), 968-977; https://doi.org/10.3390/91100968 - 30 Nov 2004

Cited by 12 | Viewed by 7504

Abstract

The polycondensation of tetrahydrofuran with maleic anhydride catalyzed byMaghnite-H⁺ (Mag-H) was investigated. Maghnite is a montmorillonite sheet silicateclay that is exchanged with protons to produce Maghnite-H [1]. It was found that thepolymerization in bulk is initiated by Mag-H in the presence of [...] Read more.

The polycondensation of tetrahydrofuran with maleic anhydride catalyzed byMaghnite-H⁺ (Mag-H) was investigated. Maghnite is a montmorillonite sheet silicateclay that is exchanged with protons to produce Maghnite-H [1]. It was found that thepolymerization in bulk is initiated by Mag-H in the presence of acetic anhydride at 40°C.The effects of the amounts of Mag-H and acetic anhydride were studied. Thepolymerization yield increased as the proportions of catalyst and acetic anhydride wereincreased. Full article

► Show Figures

Figure 1

194 KiB

Open AccessArticle

New 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Derivatives

by Mousa Al-Smadi and Samer Ratrout

Molecules 2004, 9(11), 957-967; https://doi.org/10.3390/91100957 - 30 Nov 2004

Cited by 25 | Viewed by 10764

Abstract

New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, 14-23, were prepared from the ketones 1-5 via the corresponding semicarbazones or hydrazones 6-12. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives. The intermediate 13 was also trapped, separated [...] Read more.

New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, 14-23, were prepared from the ketones 1-5 via the corresponding semicarbazones or hydrazones 6-12. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives. The intermediate 13 was also trapped, separated and fully characterized. These derivatives are important for photocrosslinking processes and due to their potential biological activity. Full article

► Show Figures

Figure 1

444 KiB

Open AccessArticle

Synthesis and Characterization of the Complexes of Pentane-2,4-dione with Nickel(II) and Cobalt(III): [Ni(acac)₂]·0.5CH₃OH and [Co(acac)₂NO₃]·2H₂O (acac = Pentane-2,4-dione)

by Yang Qu, Hai-Liang Zhu, Zhong-Lu You and Min-Yu Tan

Molecules 2004, 9(11), 949-956; https://doi.org/10.3390/91100949 - 30 Nov 2004

Cited by 9 | Viewed by 12203

Abstract

Two mononuclear complexes, [Ni(acac)2]·0.5CH₃OH (1) and[Co(acac)₂NO₃]·2H₂O (2) (acac = pentane-2,4-dione), have been synthesized andcharacterized by single crystal X-ray analysis. Complex 1 crystallizes in the monoclinicspace group P21/c with a = 9.295(4), b = 11.450(5), c [...] Read more.

Two mononuclear complexes, [Ni(acac)2]·0.5CH₃OH (1) and[Co(acac)₂NO₃]·2H₂O (2) (acac = pentane-2,4-dione), have been synthesized andcharacterized by single crystal X-ray analysis. Complex 1 crystallizes in the monoclinicspace group P21/c with a = 9.295(4), b = 11.450(5), c = 12.974(6) å, V = 1379.1(11) å³,β = 92.854(7), and Z = 4. Complex 2 crystallizes in the triclinic space group P(-1) with a= 8.153(9), b = 9.925(11), c = 10.355(12), V = 746.3(15) å³, α = 70.530(16), β =71.154(15), γ = 80.698(16) and Z = 2. Complex 1 has a one-dimensional chain-likestructure, which is extended by weak hydrogen contacts, while complex 2 shows a three–dimensional network structure. Full article

► Show Figures

Figure 1

214 KiB

Open AccessArticle

Asymmetric Synthesis and Antimicrobial Activity of Some New Mono and Bicyclic β-Lactams

by A. A. Jarrahpour, M. Shekarriz and A. Taslimi

Molecules 2004, 9(11), 939-948; https://doi.org/10.3390/91100939 - 30 Nov 2004

Cited by 24 | Viewed by 7403

Abstract

Reaction of the amino acid D-phenylalanine ethyl ester (4) with cinnamaldehyde gave chiral Schiff base 5, which underwent an asymmetric Staudinger [2+2] cycloaddition reaction with phthalimidoacetyl chloride to give the monocyclic β-lactam 6 as a single stereoisomer. Ozonolysis of 6 followed by reduction [...] Read more.

Reaction of the amino acid D-phenylalanine ethyl ester (4) with cinnamaldehyde gave chiral Schiff base 5, which underwent an asymmetric Staudinger [2+2] cycloaddition reaction with phthalimidoacetyl chloride to give the monocyclic β-lactam 6 as a single stereoisomer. Ozonolysis of 6 followed by reduction with lithium aluminum tri(tert-butoxy) hydride afforded the hydroxymethyl β-lactam 8. Treatment of 8 with methansulfonyl chloride gave the mesylated monocyclic β-lactam 9, which was converted to the bicyclic β-lactam 10 upon treatment with 1,8-diazabicyclo[5,4.0] undec- 7-ene (DBU). Deprotection of the phthalimido group in β-lactams 6 and 10 by methylhydrazine and subsequent acylation of the free amino β-lactams with different acyl chlorides in the presence of pyridine afforded mono and bicyclic β-lactams 14a-d and 15a-d respectively. The compounds prepared were tested against Escherichia coli, Staphilococcus citrus, Klebsiella pneumanie and Bacillus subtillis. Some of these compounds showed potential antimicrobial activities. Full article

► Show Figures

Figure 1

247 KiB

Open AccessArticle

Quantum Chemical and Experimental Studies on the Mechanism of Alkylation of β-Dicarbonyl Compounds. The Synthesis of Five and Six Membered Heterocyclic Spiro Derivatives

by Nurettin Sadikov, Sahin Nasibov, Cemil Ogretir, Halil Berber and Ali Hüseyinli

Molecules 2004, 9(11), 922-938; https://doi.org/10.3390/91100922 - 30 Nov 2004

Cited by 2 | Viewed by 8391

Abstract

The alkylation of β-dicarbonyl compounds in a K₂CO₃/DMSO system wasfound to afford O- and C-alkylated derivatives, depending on the type of the β-dicarbonylcompound involved. The alkyl derivatives obtained were used in the synthesis of some newspiro barbituric acid derivatives. [...] Read more.

The alkylation of β-dicarbonyl compounds in a K₂CO₃/DMSO system wasfound to afford O- and C-alkylated derivatives, depending on the type of the β-dicarbonylcompound involved. The alkyl derivatives obtained were used in the synthesis of some newspiro barbituric acid derivatives. Quantum chemical calculations were carried out toelucidate the reaction mechanisms for some typical synthesis. Full article

► Show Figures

Figure 1

216 KiB

Open AccessArticle

Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings

by Liang-Zhong Xu, Shu-Sheng Zhang, Shu-Yan Niu, Yong-Qi Qin, Xue-Mei Li and Kui Jiao

Molecules 2004, 9(11), 913-921; https://doi.org/10.3390/91100913 - 30 Nov 2004

Cited by 13 | Viewed by 9962

Abstract

Thirteen new triazoles containing 1,3-dioxolane rings were synthesized and their identities confirmed by means of IR, NMR, MS, elemental analysis and X-ray crystallography. The results of preliminary biological tests show that all of these compounds possess some fungicidal and plant growth regulant activities. [...] Read more.

Thirteen new triazoles containing 1,3-dioxolane rings were synthesized and their identities confirmed by means of IR, NMR, MS, elemental analysis and X-ray crystallography. The results of preliminary biological tests show that all of these compounds possess some fungicidal and plant growth regulant activities. Full article

► Show Figures

Figure 1

241 KiB

Open AccessArticle

Koenigs-Knorr Synthesis of Cycloalkyl Glycosides

by Zdenek Wimmer, Lucie Pechova and David Saman

Molecules 2004, 9(11), 902-912; https://doi.org/10.3390/91100902 - 30 Nov 2004

Cited by 24 | Viewed by 9528

Abstract

Cadmium carbonate was found to be a useful promoter in the Koenigs-Knorrsynthesis of 2-(4-methoxybenzyl)cyclohexyl-β-D-glycopyranosides. Using this promotermodel glucoside and galactoside derivatives of cyclic (i.e., secondary) alcohols weresynthesized in 50–60 % overall yields. Diastereoisomeric mixtures of products wereobtained in these syntheses, which started from [...] Read more.

Cadmium carbonate was found to be a useful promoter in the Koenigs-Knorrsynthesis of 2-(4-methoxybenzyl)cyclohexyl-β-D-glycopyranosides. Using this promotermodel glucoside and galactoside derivatives of cyclic (i.e., secondary) alcohols weresynthesized in 50–60 % overall yields. Diastereoisomeric mixtures of products wereobtained in these syntheses, which started from racemic isomers of 2-(4-methoxy-benzyl)cyclohexanol. The prepared compounds have been purified and characterized bytheir ¹H- and ¹³C-NMR spectra, as well as by their IR and MS spectra, in order to usethem as reference compounds in planned subsequent research. Full article

► Show Figures

Figure 1

Journal Menu

Journal Browser

Molecules, Volume 9, Issue 11 (November 2004) – 8 articles , Pages 902-987

Further Information

Guidelines

MDPI Initiatives

Follow MDPI