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Molecules, Volume 7, Issue 4 (April 2002) – 5 articles , Pages 374-411

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104 KiB

Open AccessArticle

Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423

by Stanislav Gobec and Uroš Urleb

Molecules 2002, 7(4), 394-404; https://doi.org/10.3390/70400394 - 02 May 2002

Cited by 14 | Viewed by 8534

Abstract

A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between Lalanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogues 5 and 9. Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate 14. The scope and limitations of the synthetic strategies employed are discussed. Full article

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38 KiB

Open AccessArticle

Synthesis of Platinum Complexes from N-Benzyl-1,3-Propanediamine Derivatives, Potential Antineoplastic Agents

by Mauro Vieira De Almeida, Ana Paula Soares Fontes, Richard Nilton Berg, Eloi Teixeira César, Emanoel De Castro Antunes Felício and José Dias De Souza Filho

Molecules 2002, 7(4), 405-411; https://doi.org/10.3390/70400405 - 30 Apr 2002

Cited by 8 | Viewed by 9064

Abstract

This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K₂[PtCl₄] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents. Full article

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39 KiB

Open AccessArticle

Synthesis of Mixed Carbonates via a Three-Component Coupling of Alcohols, CO₂, and Alkyl Halides in the Presence of K₂CO₃ and Tetrabutylammonium Iodide

by Min Shi and Yu-Mei Shen

Molecules 2002, 7(4), 386-393; https://doi.org/10.3390/70400386 - 30 Apr 2002

Cited by 17 | Viewed by 9840

Abstract

Various mixed carbonates can be conveniently prepared in good yields using the corresponding alcohols, alkyl halides under CO₂ atmosphere in the presence of potassium carbonate or sodium carbonate and tetrabutylammonium iodide. Full article

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26 KiB

Open AccessArticle

Synthesis of New Active Sulfones in the 5-Nitroimidazole Series

by Kamel Benakli, Thierry Terme and Patrice Vanelle

Molecules 2002, 7(4), 382-385; https://doi.org/10.3390/70400382 - 30 Apr 2002

Cited by 18 | Viewed by 7626

Abstract

We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology. Full article

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