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Molecules, Volume 7, Issue 12 (December 2002) – 11 articles , Pages 854-921

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30 KiB  
Article
Synthesis of 3-Alkenyl-1-azaanthraquinones via Diels-Alder and Electron Transfer Reactions
by Pascal Rathelot, Vincent Rémusat and Patrice Vanelle
Molecules 2002, 7(12), 917-921; https://doi.org/10.3390/71200917 - 31 Dec 2002
Cited by 8 | Viewed by 6843
Abstract
A convenient route to 3-alkenyl-1-azaanthraquinones via a hetero Diels-Alder reaction between an azadiene and naphthoquinone, a free radical chlorination and an electron transfer reaction is reported. Full article
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51 KiB  
Article
Synthesis of 2-(5-Nitropyrid-2-yl)-3-(4-substitutedphenyl)aminoisoxazol-5(2H)-ones and Their Rearrangements to Imidazo[1,2-a]- pyridines and Indoles with Triethylamine
by J. Khalafy, D. Setamdideh and K. Akbari Dilmaghani
Molecules 2002, 7(12), 907-916; https://doi.org/10.3390/71200907 - 31 Dec 2002
Cited by 10 | Viewed by 7681
Abstract
3-(4-Substitutedphenyl)aminoisoxazol-5(2H)-ones, substituted on nitrogen with a nitropyridine group, react with triethylamine to give imidazo[1,2-a]pyridines and indoles. With 4-bromophenyl and 4-methylphenyl group substituents only imidazopyridines are formed, but the 4-methoxyphenyl derivative gave a 3:1 mixture of the corresponding imidazo[1,2-a]pyridine and 2-pyridylaminoindole, respectively. Full article
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20 KiB  
Article
Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols
by Lothar W. Bieber and Maria C. F. De Araújo
Molecules 2002, 7(12), 902-906; https://doi.org/10.3390/71200902 - 31 Dec 2002
Cited by 46 | Viewed by 14918
Abstract
Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines are presented. The unsubstituted parent compound and its less hindered homologues can be obtained in high yields by tosylation and in situ cyclisation effected by potassium hydroxide [...] Read more.
Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines are presented. The unsubstituted parent compound and its less hindered homologues can be obtained in high yields by tosylation and in situ cyclisation effected by potassium hydroxide in water/dichloromethane. Higher substituted amino alcohols give better yields using potassium carbonate in acetonitrile. Both procedures use simple inorganic bases and produce only inorganic salts as byproducts. Full article
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96 KiB  
Article
Determination of Aldehyde Dehydrogenase (ALDH) Isozymes in Human Cancer Samples - Comparison of Kinetic and Immunochemical Assays
by Piotr Wroczynski, Jacek Wierzchowski, Jakub Golab, Magdalena Blazejczyk and Dorota Borecka
Molecules 2002, 7(12), 896-901; https://doi.org/10.3390/71200896 - 31 Dec 2002
Cited by 1 | Viewed by 8604
Abstract
A fluorimetric assay of aldehyde dehydrogenase isozymes, based on naphthaldehyde oxidation, is compared with Western Blotting analysis on several clinical samples obtained from surgery. The comparison reveals qualitatively good correlation of ALDH1A1 isozyme detection with two methods and somewhat worse on ALDH3A1 assay. [...] Read more.
A fluorimetric assay of aldehyde dehydrogenase isozymes, based on naphthaldehyde oxidation, is compared with Western Blotting analysis on several clinical samples obtained from surgery. The comparison reveals qualitatively good correlation of ALDH1A1 isozyme detection with two methods and somewhat worse on ALDH3A1 assay. Full article
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397 KiB  
Article
Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity
by Davood Azarifar and Maseud Shaebanzadeh
Molecules 2002, 7(12), 885-895; https://doi.org/10.3390/71200885 - 31 Dec 2002
Cited by 174 | Viewed by 13445 | Correction
Abstract
A number of chalcones were prepared by condensing either 1-acetylnaphthalene or substituted 1-acetylnaphthalenes with 1-naphthaldehyde or 4-dimethylamino-1-naphthaldehyde in ethanolic NaOH solutions. These chalcones were immediately reacted with hydrazine hydrochloride, phenyl hydrazine and semicarbazide hydrochloride in the presence of dry acetic acid to obtain [...] Read more.
A number of chalcones were prepared by condensing either 1-acetylnaphthalene or substituted 1-acetylnaphthalenes with 1-naphthaldehyde or 4-dimethylamino-1-naphthaldehyde in ethanolic NaOH solutions. These chalcones were immediately reacted with hydrazine hydrochloride, phenyl hydrazine and semicarbazide hydrochloride in the presence of dry acetic acid to obtain the corresponding 2-pyrazolines. The synthesised heterocycles were characterized on the basis of their chemical properties and spectroscopic data. These compounds were tested for antimicrobial activity against a variety of test organisms: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabillis, Shigella dysentry and Salmonella typhii. The compounds containing chloro, hydroxo and dimethylamino - N(CH3)2 group as substituents on the naphthalene rings have been found to be very effective antimicrobial agents. In addition, the presence of a carboxamido -CONH2 substituent group at the N-1 position of the 2-pyrazoline rings is shown to contribute substantially to the antimicrobial activity. Full article
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143 KiB  
Article
Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series
by Davorka Pavlicic, Jasna Dogan Koružnjak, Zrinka Banic-Tomišic and Grace Karminski-Zamola
Molecules 2002, 7(12), 871-884; https://doi.org/10.3390/71200871 - 31 Dec 2002
Cited by 8 | Viewed by 8500
Abstract
Three new heterocyclic substituted dianilides, namely 3-chloro-5-[1-(pfluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]thieno-[3,2-b]thiophene-2-carboxy-p-fluoroanilide (8), 1,2-bis{5-[2-(p-fluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]-2-thienyl}ethene (13) and 6-chloro-2-{2-[3-chloro-2-(p-fluorophenyl-carbamoyl)-5-thieno[3,2-b]thienyl]-2-ethoxycarbonylethenyl}thieno[3,2-b]furan-5-carboxy-p-fluoroanilide (20) were prepared by multistep synthesis. The prepared dianilides are of particular interest for their potential to serve as the planar heteroaromatic core of DNA intercalators or groove binders. Full article
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22 KiB  
Article
Microwave-Accelerated Iodination of Some Aromatic Amines, Using Urea-Hydrogen Peroxide Addition Compound (UHP) as the Oxidant
by Maciej Sosnowski and Lech Skulski
Molecules 2002, 7(12), 867-870; https://doi.org/10.3390/71200867 - 31 Dec 2002
Cited by 22 | Viewed by 8076
Abstract
A fast and simple method for the oxidative iodination of some aromatic amines, under microwave irradiation, is reported, using diiodine and the the strongly Hbonded urea-hydrogen peroxide addition compound (H2NCONH2···H2O2, UHP) as the oxidant. [...] Read more.
A fast and simple method for the oxidative iodination of some aromatic amines, under microwave irradiation, is reported, using diiodine and the the strongly Hbonded urea-hydrogen peroxide addition compound (H2NCONH2···H2O2, UHP) as the oxidant. The reactions were carried out in boiling CHCl3 under a reflux condenser to afford, within 10 minutes, the purified monoiodinated products in 40-80% yields. Full article
39 KiB  
Article
Electrochemical Anion Recognition By Novel Ferrocenyl Imidazole Systems
by Jean-Luc Thomas, Joshua Howarth and Anthony M. Kennedy
Molecules 2002, 7(12), 861-866; https://doi.org/10.3390/71200861 - 31 Dec 2002
Cited by 29 | Viewed by 9527
Abstract
A novel class of anion receptors with with C-H···X- hydrogen bonding is introduced and demonstrated for Cl-, Br-, NO3- and HSO4- recognition. Cyclic voltammetry revealed that novel ferrocenylimidazolium salts, syntheses of which are briefly [...] Read more.
A novel class of anion receptors with with C-H···X- hydrogen bonding is introduced and demonstrated for Cl-, Br-, NO3- and HSO4- recognition. Cyclic voltammetry revealed that novel ferrocenylimidazolium salts, syntheses of which are briefly described, selectively complex and electrochemically recognise guest anions. Futhermore, proton NMR spectroscopy indicated the formation of 1:2 stoichiometric complexes with Cl-, Br and I- and 1:1 stoichiometric complexes with NO3- and HSO4-. Full article
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245 KiB  
Editorial
New Development: A Printed Edition
by Francis F. Muguet, Shu-Kun Lin and Derek J. McPhee
Molecules 2002, 7(12), 858-860; https://doi.org/10.3390/71200858 - 31 Dec 2002
Cited by 3 | Viewed by 5609
16 KiB  
Editorial
A New Editorial Office in Qingdao, a New E-Publishing System for MDPI Journals and Beilstein Starts Coverage of Molecules
by Shu-Kun Lin, Derek J. McPhee and Francis F. Muguet
Molecules 2002, 7(12), 855-857; https://doi.org/10.3390/71200855 - 31 Dec 2002
Cited by 2 | Viewed by 6253
10 KiB  
Commentary
The International Symposium on Frontiers in Molecular Science 2002 (ISFMS 2002), Qingdao, China, July 15-18, 2002
by Shu-Kun Lin and Xianguo Li
Molecules 2002, 7(12), 854; https://doi.org/10.3390/71200854 - 31 Dec 2002
Cited by 1 | Viewed by 5902
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