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Molecules, Volume 5, Issue 7 (July 2000) – 24 articles , Pages 916-991, Articles M162-M171

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83 KiB  
Short Note
1-(4-Nitrophenyl)-1-octyne
by Bruce A. Hathaway and Steven W. Blanner
Molecules 2000, 5(7), M171; https://doi.org/10.3390/M171 - 30 Jul 2000
Cited by 1 | Viewed by 3146
Abstract
Following the procedure of Takahashi, et al (1), to a mixture of 1-iodo-4-nitrobenzene (7.76 mmol, 1.90g) and 1-octyne (9.3 mmol, 1.023g) in diethylamine (40 mL) are added bis[triphenylphosphine]palladium dichloride (0.2mmol, 0.14g) and copper(I) iodide (0.1mmol, 0.01g).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
86 KiB  
Short Note
5-(2-Thienylidene)barbituric Acid
by Abdullah Mohamed Asiri
Molecules 2000, 5(7), M170; https://doi.org/10.3390/M170 - 30 Jul 2000
Cited by 1 | Viewed by 4199
Abstract
5-(2-Thienylidene)barbituric acid 3 was prepared by Knoevenagel condensation of thiophene- 2-carboxaldehyde 1 and barbituric acid 2 in ethanol using piperidine as a base [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
84 KiB  
Short Note
Trimethyl(trifluorovinyl)silane
by Roxana M. Trifu and George L. Gould
Molecules 2000, 5(7), M169; https://doi.org/10.3390/M169 - 30 Jul 2000
Viewed by 3410
Abstract
Trimethyl(trifluorovinyl)silane was prepared [1] without characterization details from bromotrifluoroethylene, which is not commercially available.[...] Full article
12 KiB  
New Book Received
Organic Synthesis on Solid Phase. By Florencio Zaragoza Dörwald
by Shu-Kun Lin
Molecules 2000, 5(7), 990-991; https://doi.org/10.3390/50700990 - 26 Jul 2000
Viewed by 4010
Abstract
Organic synthesis on solid supports is a rapidly developing methodology, which offers several advantages if compared to traditional synthesis in solution.[...] Full article
12 KiB  
New Book Received
Pharmacophore Perception, Development and Use in Drug Design. Edited by Osman F. Güner
by Shu-Kun Lin
Molecules 2000, 5(7), 987-989; https://doi.org/10.3390/50700987 - 26 Jul 2000
Cited by 26 | Viewed by 7609
Abstract
The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.[...] Full article
33 KiB  
Article
Synthesis and Antifungal Activity of Musa Phytoalexins and Structural Analogs
by Winston Quiñones, Gustavo Escobar, Fernando Echeverri, Fernando Torres, Yoni Rosero, Victor Arango, Gloria Cardona and Adriana Gallego
Molecules 2000, 5(7), 974-980; https://doi.org/10.3390/50700974 - 26 Jul 2000
Cited by 44 | Viewed by 9288
Abstract
Several perinaphthenone/phenylphenalenone compounds were synthesized to establish a relationship between structure and antifungal activity against Mycosphaerella fijiensis. Substitutions on the unsaturated carbonyl system or addition of a phenyl group reduced antibiotic activity. Full article
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14 KiB  
New Book Received
Classics in Hydrocarbon Chemistry. By Henning Hopf
by Shu-Kun Lin
Molecules 2000, 5(7), 985-986; https://doi.org/10.3390/50700985 - 25 Jul 2000
Viewed by 4441
Abstract
Carbon and Hydrogen: the two basic building units can be combined in a million different ways to give a plethora of fascinating organic compounds.[...] Full article
12 KiB  
New Book Received
Applied Thin-Layer Chromatography. By Elke Hahn-Deinstrop
by Shu-Kun Lin
Molecules 2000, 5(7), 983-984; https://doi.org/10.3390/50700983 - 25 Jul 2000
Cited by 1 | Viewed by 5348
Abstract
Thin layer chromatography (TLC) is a powerful, fast and inexpensive analytical method.[...] Full article
38 KiB  
Article
Photolytic Cleavage and Condensation Reactions of Cyclohexa-2,4-dienones with Diamines
by Young Mee Kim, Suk Jin Song, Tae Woo Kwon and Sung Kee Chung
Molecules 2000, 5(7), 961-966; https://doi.org/10.3390/50700961 - 23 Jul 2000
Cited by 2 | Viewed by 7083
Abstract
Cyclohexa-2,4-diene-1-one sulfone derivate undergoes ring cleavage to afford bis-amides containing a diene moiety on irradiation with visible light in the presence of various diamines. Full article
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13 KiB  
New Book Received
Modern Carbonyl Chemistry. Edited by Junzo Otera
by Shu-Kun Lin
Molecules 2000, 5(7), 981-982; https://doi.org/10.3390/50700981 - 20 Jul 2000
Cited by 1 | Viewed by 4195
Abstract
The carbonyl group is undoubtedly one of the most important functional groups in organic chemistry, both in its role as reactive center for synthesis or derivatisation and as crucial feature for special structural or physiological properties.[...] Full article
22 KiB  
Article
Selective ipso-Nitration of tert-Butylcalix[4]arene Tripropylether
by Parviz Rashidi-Ranjbar, Saeed Taghvaei-Ganjali, Behrouz Shaabani and Karim Akbari
Molecules 2000, 5(7), 941-944; https://doi.org/10.3390/50700941 - 10 Jul 2000
Cited by 13 | Viewed by 6611
Abstract
An improved selective ipso-nitration of the tripropoxy derivative of tertbutylcalix[4]arene at the upper rim is described. The synthesized products are key intermediates for construction of molecular receptors based on calixarenes. Full article
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87 KiB  
Short Note
1-(2-Benzylaminophenyl)-2-phenylbenzimidazole
by Ke-Qing Zhao, Ping Hu, Shi-Lin Zhao and Hong-Bo Xu
Molecules 2000, 5(7), M168; https://doi.org/10.3390/M168 - 10 Jul 2000
Cited by 1 | Viewed by 3901
Abstract
When the imine-amine compound, bis[(2-benzylideneimino)phenyl]amine [1], is heated in presence of a transition metal salt (for example FeCl3), a reaction occur leading to a new compound.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
18 KiB  
Short Note
Bis[(2-benzylideneimino)phenyl]amine
by Ke-Qing Zhao, Ping Hu, Quan Li and Hong-Bo Xu
Molecules 2000, 5(7), M167; https://doi.org/10.3390/M167 - 10 Jul 2000
Cited by 1 | Viewed by 3803
Abstract
Imine and amine ligands have been widely used in the field of transition metal catalyzed olefin polymerization [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
89 KiB  
Short Note
1,2-Ethylene-bis(o-N2-phenylene-N1,N1-dimethylformamidine)
by Sergiu Coseri and Adrian A. Caraculacu
Molecules 2000, 5(7), M166; https://doi.org/10.3390/M166 - 10 Jul 2000
Cited by 1 | Viewed by 3061
Abstract
A mixture of 3.71 mmol (0.98 g) of bibenzil-2,2-di-yl-diisocyanate (1) [1] and 74.16mmol (5.42 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring for 8 h, with complete absorption of any carbon dioxide in aqueous potassium hydroxide solution [2]. Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
89 KiB  
Short Note
1,2-Ethylene-bis(p-N2-phenylene-N1,N1-dimethylformamidine)
by Sergiu Coseri and Adrian A. Caraculacu
Molecules 2000, 5(7), M165; https://doi.org/10.3390/M165 - 10 Jul 2000
Cited by 1 | Viewed by 2939
Abstract
A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon dioxide in aqueous [...] Read more.
A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon dioxide in aqueous potassium hydroxide solution [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
89 KiB  
Short Note
6-Amino-2-phenylimidazo[4,5-e][1,3]diazepine-4,8(1H, 5H)-dione
by Huan-Ming Chen and Ramachandra S. Hosmane
Molecules 2000, 5(7), M164; https://doi.org/10.3390/M164 - 10 Jul 2000
Cited by 2 | Viewed by 4005
Abstract
The starting imidazole diester (1) was prepared by esterification of the corresponding dicarboxylic acid acccording to the literature procedure [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
119 KiB  
Short Note
Cycloeucalen-3ß-(2-methyl Butanoate). New Cycloeucalen Isolated from the Espeletia barclayana Cuatr (Asteraceae)
by Tellez Alba Nohemi, Torrenegra Ruben, Pedrozo Julio and Martínez Astrid
Molecules 2000, 5(7), M163; https://doi.org/10.3390/M163 - 10 Jul 2000
Cited by 3 | Viewed by 3461
Abstract
Continuing our studies of the Espeletia barclayana Cuatr.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
Short Note
N-(9-Fluorenylmethoxycarbonyl)-L-serine Amide
by Zoltán Schmél and Zoltán Kupihár
Molecules 2000, 5(7), M162; https://doi.org/10.3390/M162 - 10 Jul 2000
Cited by 1 | Viewed by 3367
Abstract
The synthesis of N-Fmoc-L-serine amide was performed by the well known Schotten-Baumann acylation method [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
18 KiB  
Article
Mass Spectra of Some 4- and 5-Substituted Derivatives of Benzoselenadiazoles
by Ján Leško, Viktor Milata and Marcel Schultz
Molecules 2000, 5(7), 937-940; https://doi.org/10.3390/50700937 - 9 Jul 2000
Cited by 2 | Viewed by 5754
Abstract
Electron impact mass spectra of variety of eight 4-substituted and eight 5-substituted benzoselenadiazoles are presented and their spectral fragmentations are discussed. New mass spectra containing selenium in heterocyclic azole atom containing ring. Full article
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144 KiB  
Article
Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors
by Gautam R. Desiraju, Bulusu Gopalakrishnan, Ram K. R. Jetti, Dayam Raveendra, Jagarlapudi A. R. P. Sarma and Hosahalli S. Subramanya
Molecules 2000, 5(7), 945-955; https://doi.org/10.3390/50700945 - 8 Jul 2000
Cited by 34 | Viewed by 8172
Abstract
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase-2 (COX-2) inhibitors, using three different methods: comparative molecular field [...] Read more.
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase-2 (COX-2) inhibitors, using three different methods: comparative molecular field analysis (CoMFA) with partial least squares (PLS) fit; molecular field analysis (MFA) and; receptor surface analysis (RSA) with genetic function algorithms (GFA). The analyses were carried out on 30 analogues of which 25 were used in the training set and the rest considered for the test set. These studies produced reasonably good predictive models with high cross-validated and conventional r2 values in all the three cases. Full article
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42 KiB  
Article
Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids
by Emil Popovski, Ljiljana Klisarova and Drazen Vikic-Topic
Molecules 2000, 5(7), 927-936; https://doi.org/10.3390/50700927 - 7 Jul 2000
Cited by 18 | Viewed by 7978
Abstract
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as [...] Read more.
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane. Full article
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69 KiB  
Article
Novel Behavior of Thiiranium Radical Cation Intermediates. Reactions of Dimethyl Disulfide with Alkenes in the Presence of Pd(OAc)2
by Hiroshi Takeuchi, Junnichi Takatori and Shingo Iizuka
Molecules 2000, 5(7), 916-926; https://doi.org/10.3390/50700916 - 7 Jul 2000
Cited by 2 | Viewed by 7810
Abstract
Reaction of dimethyl disulfide (1) with cyclohexene (2a) in AcOH in the presence of Pd(OAc)2 yields trans-1-acetoxy-2-methylcyclohexane (3a). The equivalent reactions with hex-1-ene (2b) and 2-methylpent-1-ene (2c) or 1-methylcyclohex-1-ene (2d) preferentially give anti-Markovnikov and Markovnikov adducts 4 and 3, respectively, [...] Read more.
Reaction of dimethyl disulfide (1) with cyclohexene (2a) in AcOH in the presence of Pd(OAc)2 yields trans-1-acetoxy-2-methylcyclohexane (3a). The equivalent reactions with hex-1-ene (2b) and 2-methylpent-1-ene (2c) or 1-methylcyclohex-1-ene (2d) preferentially give anti-Markovnikov and Markovnikov adducts 4 and 3, respectively, by acetoxymethylthiolation of the alkene. The Markovnikov regioselectivity 3b/4b for the reaction with 2b is higher than that for the reaction using AgOAc instead of Pd(OAc)2, which proceeds via a thiiranium ion. Addition of a polar solvent (MeCN or MeNO2) to the reactions with 2b or 2c using Pd(OAc)2 abnormally decreases the Markovnikov regioselectivity. The total yield of 3 and 4 increases with an increased concentration of AcOH. Compounds 3 and 4 are also formed and the reactions in MeCN or MeNO2 not containing AcOH. A solution of Pd(OAc)2 in 1 exhibits λmax 380 nm (log ε 3.6) assigned to the absorption of a relatively stable sulfonium salt. These indicate that the reactions using Pd(OAc)2 proceed by SN2 ringopening of a new type of thiiranium radical cations paired with −OAc via the sulfonium salts. The insensitivity of the 3/4 ratios to the reaction time at 25-60°C in the reactions with 2c-d shows the ring-opening to be controlled kinetically, but the increased ratio with reaction time at 116°C in the reaction with 2b suggests that the ring-opening is thermodynamically governed. The reaction product with 2d also undergoes a skeletal rearrangement to a thietanium radical cation to give 1-acetoxymethyl-2-methylthiocyclohexane. Full article
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31 KiB  
Article
Spectral Characteristics of 2,7-Naphthyridines
by Eugen Barbu, Dan Mihaiescu and Flavian Cuiban
Molecules 2000, 5(7), 956-960; https://doi.org/10.3390/50700956 - 27 Jun 2000
Cited by 5 | Viewed by 5918
Abstract
Substituent increments for the calculation of 1H- and 13C-NMR spectra and the MS characteristics of 2,7-naphthyridines substituted on one ring are presented. Full article
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50 KiB  
Article
Reactions with Hydrazonoyl Halides. 31. Synthesis of Some New Pyrrolidino[3,4-c]pyrazolines, Pyrazoles, and Pyrazolo[3,4-d]pyridazines
by Abdou O. Abdelhamid, Hussien F. Zohdi, Mohamed M. M. Sallam and Nagla A. Ahmed
Molecules 2000, 5(7), 967-973; https://doi.org/10.3390/50700967 - 21 Jun 2000
Cited by 20 | Viewed by 9425
Abstract
Pyrrolidino[3,4-c]pyrazoline and pyrazole derivatives were synthesized via reactions of a substituted hydrazonoyl bromide with N-arylmaleimides and active methylene reagents, respectively. Synthesized pyrazoles were reacted with hydrazine hydrate to give the corresponding pyrazolo[3,4-d]pyridazines. Full article
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Scheme 1

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