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Molecules, Volume 5, Issue 4 (April 2000) – 25 articles , Pages 637-700, Articles M144-M161

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102 KiB  
Short Note
A New Heterocyclization Product of Adhyperforin from Hypericum perforatum (St. John's Wort)
by Suzana Vugdelija, Vlatka Vajs, Snezana Trifunovic, Dejan Djokovic and Slobodan Milosavljevic
Molecules 2000, 5(4), M158; https://doi.org/10.3390/M158 - 30 Apr 2000
Cited by 8 | Viewed by 4434
Abstract
From the aerial parts of Hypericum perforatum L. we have isolated phloroglucinol 1 (see the formula), a homologue of 2, the latter isolated previously from the same extract and identified by 2D NMR (DQF COSY, PS NOESY, TOCSY, HSQC and HMBC) [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
87 KiB  
Short Note
Menthyl 2-Benzyl-2-phenylsulfonyl Acetate
by Mohammed Ramdani and Abderrahmane Elidrissi
Molecules 2000, 5(4), M146; https://doi.org/10.3390/M146 - 29 Apr 2000
Viewed by 2822
Abstract
The product 2 was prepared from menthyl phenylsulfonyl acetate in situ by the solid-liquid PTC conditions without solvent.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
85 KiB  
Short Note
N,N-Dibutyl-2-p-tolyl-acetamide
by Olivier Comte, Sylvie Genillard and Céline Nkubana
Molecules 2000, 5(4), M161; https://doi.org/10.3390/M161 - 28 Apr 2000
Viewed by 3089
Abstract
Thionyl chloride (2.18 ml, 3.56 g, 30 mmol, 1.5 eq) was added dropwise to a vigorously stirred solution of p-tolylacetic acid (3 g, 20 mmol, 1 eq) and heated to 100°C for 3 hours.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
88 KiB  
Short Note
2-Chloro-3-(4-morpholino)-1,4-naphthoquinone
by Sukanta Bhattacharyya
Molecules 2000, 5(4), M160; https://doi.org/10.3390/M160 - 28 Apr 2000
Cited by 3 | Viewed by 3519
Abstract
The title compound, a novel electron donor-acceptor system [1] was prepared [2] by refluxing a suspension of commercially available 2,3-dichloro-1,4-naphthoquinone in absolute ethanol and morpholine in the presence of anhydrous potassium carbonate.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-(N,N-Dimethylamino)adamantane
by Sukanta Bhattacharyya
Molecules 2000, 5(4), M159; https://doi.org/10.3390/M159 - 28 Apr 2000
Cited by 2 | Viewed by 3243
Abstract
The title compound, an important antiviral agent [1] was prepared from commercially available 1-aminoadamantane by titanium(IV) isopropoxide mediated reductive amination of formaldehyde [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-ethoxycarbonylmethyl-5-bromo-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M157; https://doi.org/10.3390/M157 - 28 Apr 2000
Viewed by 2934
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-allyl-5-bromo-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M156; https://doi.org/10.3390/M156 - 28 Apr 2000
Viewed by 2543
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-benzyl-5-bromo-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M155; https://doi.org/10.3390/M155 - 28 Apr 2000
Viewed by 3009
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-ethyl-5-bromo-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M154; https://doi.org/10.3390/M154 - 28 Apr 2000
Viewed by 2582
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-methyl-5-bromo-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M153; https://doi.org/10.3390/M153 - 28 Apr 2000
Viewed by 2578
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-ethoxycarbonylmethyl-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M152; https://doi.org/10.3390/M152 - 28 Apr 2000
Viewed by 2609
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-allyl-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M151; https://doi.org/10.3390/M151 - 28 Apr 2000
Viewed by 2539
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-benzyl-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M150; https://doi.org/10.3390/M150 - 28 Apr 2000
Viewed by 2580
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-ethyl-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M149; https://doi.org/10.3390/M149 - 28 Apr 2000
Viewed by 2612
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
222 KiB  
Short Note
1-[(2-Acetoxyethoxy)methyl]-3-methyl-6-azauracil
by Smaail Radi and Hassan B. Lazrek
Molecules 2000, 5(4), M148; https://doi.org/10.3390/M148 - 28 Apr 2000
Viewed by 2907
Abstract
The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
88 KiB  
Short Note
2,4,6-Tris(2',4',6'-trimethylphenylethynyl)mesitylene
by Laura Jeffries and Eric Bosch
Molecules 2000, 5(4), M147; https://doi.org/10.3390/M147 - 28 Apr 2000
Viewed by 2477
Abstract
The experimental procedure follows the general synthesis of arylalkynes reported by Sonogashira [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
84 KiB  
Short Note
Menthyl Phenylsulfonyl Acetate
by Mohammed Ramdani and Abderrahmane Elidrissi
Molecules 2000, 5(4), M145; https://doi.org/10.3390/M145 - 28 Apr 2000
Viewed by 3071
Abstract
Menthyl phenylsulfonyl acetate was prepared from methyl phenylsulfonyl acetate by solid-liquid PTC trans-esterification conditions without a solvent [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
93 KiB  
Short Note
6-S-Trityl-mercapto-hexan-1-ol
by Zoltán Kupihár, Zoltán Schmél and Lajos Kovács
Molecules 2000, 5(4), M144; https://doi.org/10.3390/M144 - 28 Apr 2000
Cited by 3 | Viewed by 4606
Abstract
6-S-Trityl-mercapto-hexan-1-ol is an important compound, because its O-b-cyanoethyl-N,N-diisopropyl phosphoramidite derivative is the most widely used building block for the synthesis of 5'-thiol modified oligonucleotides.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
5 KiB  
Book Review
Basic Mathematics for Biochemists. by Athel Cornish-Bowden
by Shu-Kun Lin
Molecules 2000, 5(4), 699-700; https://doi.org/10.3390/50400699 - 26 Apr 2000
Viewed by 4385
Abstract
This is a new edition of the book published under the same title by Chapman and Hall in 1981.[...] Full article
107 KiB  
Article
Synthesis of a Highly Functionalized Triquinane: Studies Towards a Total Synthesis of Subergorgic Acid and Its Analogues
by Veljko Dragojlovic
Molecules 2000, 5(4), 674-698; https://doi.org/10.3390/50400674 - 20 Apr 2000
Cited by 9 | Viewed by 7665
Abstract
Reaction of enone (11) with the bifunctional Grignard reagent (7) in the presence of copper(I) bromide – dimethyl sulfide, followed by intramolecular alkylation of the resultant chloroketone (15) gave the tricyclic ketone (12). The tricyclic ketone (12) was transformed into the angular triquinane [...] Read more.
Reaction of enone (11) with the bifunctional Grignard reagent (7) in the presence of copper(I) bromide – dimethyl sulfide, followed by intramolecular alkylation of the resultant chloroketone (15) gave the tricyclic ketone (12). The tricyclic ketone (12) was transformed into the angular triquinane dienedione (9) by means of an 8-step sequence. Full article
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52 KiB  
Article
Facile Synthesis of (R,R) and of (R,S) Tricarballylic Acid Anhydride and Imide Derivatives
by Abdel-Sattar S. Hamad Elgazwy
Molecules 2000, 5(4), 665-673; https://doi.org/10.3390/50400665 - 15 Apr 2000
Cited by 6 | Viewed by 8010
Abstract
The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl)succinic anhydride 6 with (R)-(α)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(α)-Methylbenzylamideformyl)]propane-2,3-dicarboxylic [...] Read more.
The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl)succinic anhydride 6 with (R)-(α)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(α)-Methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9s and 1-[(R)-(α)-methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9a was isolated as an intermediate under the reaction conditions. This diastereomeric mixture 9s/9a was also prepared by a different route via reaction of 1-(chloroformyl)propane-2,3-dicarboxylic acid anydride 12 with (R)-(α)-methylbenzylamine in the presence of DMA at 0oC for 24 hrs. Full article
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25 KiB  
Article
Thermolysis of Semicarbazones to the Corresponding Azines Through Reactive N-Substituted Isocyanate Intermediates
by S. N. Shah and N. K. Chudgar
Molecules 2000, 5(4), 657-664; https://doi.org/10.3390/50400657 - 7 Apr 2000
Cited by 27 | Viewed by 6858
Abstract
Thermolysis of semicarbazones (I) to azines (II) occurs through reactive N-substituted isocyanate intermediates (Ia) which can be converted in situ to carbamates and Nsubstituted ureas. Full article
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10 KiB  
Article
Synthesis and Elastase Inhibitory Evaluation of Phosphate Esters and Mixed Phosphate Anhydride of Penam Sulfones
by María A. Laborde and O. A. Mascaretti
Molecules 2000, 5(4), 655-656; https://doi.org/10.3390/50400655 - 5 Apr 2000
Viewed by 5881
Abstract
The evaluation of human leucocite elastase inhibition by phosphate esters (1-2) and phosphate mixed anhydride (3) of penicillin sulfones and their precursor sulfides is described. Full article
28 KiB  
Article
Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds
by Chris J. Peterson, Rong Tsao, Aimee L. Eggler and Joel R. Coats
Molecules 2000, 5(4), 648-654; https://doi.org/10.3390/50400648 - 3 Apr 2000
Cited by 39 | Viewed by 8894
Abstract
The insecticidal activities of several cyanohydrins, cyanohydrin esters and monoterpenoid esters (including three monoterpenoid esters of a cyanohydrin) were evaluated. Topical toxicity to Musca domestica L. adults was examined, and testing of many compounds at 100 mg/fly resulted in 100% mortality. Topical LD [...] Read more.
The insecticidal activities of several cyanohydrins, cyanohydrin esters and monoterpenoid esters (including three monoterpenoid esters of a cyanohydrin) were evaluated. Topical toxicity to Musca domestica L. adults was examined, and testing of many compounds at 100 mg/fly resulted in 100% mortality. Topical LD50 values of four compounds for M. domestica were calculated. Testing of many of the reported compounds to brine shrimp (Artemia franciscana Kellog) resulted in 100% mortality at 10 ppm, and two compounds caused 100% mortality at 1 ppm. Aquatic LC50 values were calculated for five compounds for larvae of the yellow fever mosquito (Aedes aegypti (L.)). Monoterpenoid esters were among the most toxic compounds tested in topical and aquatic bioassays. Full article
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121 KiB  
Article
Cycloaddition Reactions of C,N-Diphenylnitrone to Methylene-γ-butyrolactones
by Martina Cacciarini, Franca M. Cordero, Cristina Faggi and Andrea Goti
Molecules 2000, 5(4), 637-647; https://doi.org/10.3390/50400637 - 2 Apr 2000
Cited by 20 | Viewed by 9184
Abstract
Cycloaddition of C,N-diphenylnitrone to α-methylene-γ-butyrolactone afforded two diastereomeric 5-spirosubstituted isoxazolidines with high selectivity. Structural assignment was ascertained by NMR studies and an X-ray diffraction experiment on a single crystal of the major isomer and the diastereoselectivity was rationalized on examination of the alternative [...] Read more.
Cycloaddition of C,N-diphenylnitrone to α-methylene-γ-butyrolactone afforded two diastereomeric 5-spirosubstituted isoxazolidines with high selectivity. Structural assignment was ascertained by NMR studies and an X-ray diffraction experiment on a single crystal of the major isomer and the diastereoselectivity was rationalized on examination of the alternative transition states leading to the two diastereoisomers. Full article
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