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Molecules, Volume 2, Issue 9 (September 1997) – 3 articles , Pages 129-151, Article M26

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70 KiB

Open AccessShort Note

3,3-Bis(5-methylfur-2-yl)-2-oxoindoline

by Andrey V. Gutnov

Molecules 1997, 2(9), M26; https://doi.org/10.3390/M26 - 22 Sep 1997

Viewed by 3189

Abstract

To a boiling solution of isatine (3 g, 20 mmol) and sylvan (4 ml, 50 mmol) in 30 ml of dioxane one drop of 70% perchloric acid was added.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

199 KiB

Open AccessArticle

Photoisomerization of Ethyl 2–(3–Acylselenoureido)thiophene– 3–carboxylates and Their Benzoanalogues

by Pavel Pazdera, Jiri Sibor, Radek Marek, Michal Kuty and Jaromir Marek

Molecules 1997, 2(9), 135-151; https://doi.org/10.3390/20900135 - 15 Sep 1997

Cited by 9 | Viewed by 8081

Abstract

Synthesis, isomerisation and structure elucidation of the title compounds 1–6 and its isomers 7–12 by FTIR, ¹H, ¹³C, ¹⁵N, ⁷⁷Se NMR spectroscopy is reported. Ethyl 2–(3–acylselenoureido)thiophene–3–carboxylates and their benzoanalogues (where acyl is benzoyl and pivaloyl) were prepared by addition of ethyl 2–aminothiophene–3–carboxylates and ethyl 2–aminobenzoate on benzoyl– or pivaloylisoselenocyanate in acetone solution. An isomerization of 1–6 to the corresponding 3–acylisoselenoureas 7–12 was obtained. The isomerisation proceeds either by irradiation with light (340–400 nm) or in the case of benzoylderivatives 1, 3, 5 by treatment with acetic acid. On the other hand the acid action in the pivaloyl set inhibited this isomerisation and evoked the retroisomerisation reaction of 8, 10, 12 to 2, 4, 6. Thermal analyses showed that isomerisation can be initiated also by heating. These changes proceed in the solid phase as an exothermic process at an elevated temperature but always below the temperature of melting. The structure 2 was supported by X–ray analysis. Molecular design of 2 and 8 was modeled during application of ab initio quantum chemistry calculation. Full article

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26 KiB

Open AccessArticle

Improved Method for the Synthesis of New 1,5-Benzothiazepine Derivatives as Analogues of Anticancer Drugs

by Anoop K. Sharma, Gajendra Singh, Ashok K. Yadav and L. Prakash

Molecules 1997, 2(9), 129-134; https://doi.org/10.3390/20900129 - 05 Sep 1997

Cited by 24 | Viewed by 7305

Abstract

(±)cis-2-(4-Methoxyphenyl)-3-hydroxy/methoxy-2,3-dihydro-1,5-benzothiazepin-4[5H/5-chloroacetyl/5-(4'-methylpiperazino-1')acetyl]-ones have been synthesized by the condensation of 2-aminobenzene thiols with methyl(±)trans-3-(4-methoxyphenyl)glycidate in xylene. The synthesized compounds have been characterized by elemental analyses and spectral data and screened for their antimicrobial activity. Full article

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Molecules, Volume 2, Issue 9 (September 1997) – 3 articles , Pages 129-151, Article M26

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