Molecules

46 KiB

Open AccessArticle

Synthesis of New 4(3H)-Quinazolinone Derivatives Using 5(4H)-Oxazolones

by Hooshang Hamidian, Ahmad Momeni Tikdari and Hojatollah Khabazzadeh

Molecules 2006, 11(5), 377-382; https://doi.org/10.3390/11050377 - 27 May 2006

Cited by 7 | Viewed by 7409

New derivatives of 5(4H)-quinazolinone containing 2-imidazolin-5-one rings have been prepared from 5(4H)-oxazolone derivatives. Full article

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101 KiB

Open AccessArticle

Experimental and Theoretical Study of Lanthanide Complexes Based on Linear and Macrocyclic Polyaminopolycarboxylic Acids Containing Pyrazolylethyl Arms

by Elena Pérez-Mayoral, Elena Soriano, Sebastián Cerdán and Paloma Ballesteros

Molecules 2006, 11(5), 345-356; https://doi.org/10.3390/11050345 - 17 May 2006

Cited by 7 | Viewed by 9776

Abstract

We report the synthesis of two novel Gd(III)-complexes derived from linear and macrocyclic polyaminopolycarboxylic acids 1 and 2, which contain a 3,5- dimethylpyrazolyl-ethyl arm, and a study of their relaxivity properties. The relationships between the experimental and theoretical results have provided interesting information [...] Read more.

We report the synthesis of two novel Gd(III)-complexes derived from linear and macrocyclic polyaminopolycarboxylic acids 1 and 2, which contain a 3,5- dimethylpyrazolyl-ethyl arm, and a study of their relaxivity properties. The relationships between the experimental and theoretical results have provided interesting information about the kinetic and thermodynamic stability of these complexes. Full article

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58 KiB

Open AccessCommunication

First Synthesis of 3-Acetyl-2-aminothiophenes Using the Gewald Reaction

by Gernot A. Eller and Wolfgang Holzer

Molecules 2006, 11(5), 371-376; https://doi.org/10.3390/11050371 - 16 May 2006

Cited by 32 | Viewed by 10014

Abstract

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of thecorresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene – aninteresting building-block for thiophene azo dyes – are reported. Detailed spectroscopicinvestigations (¹H-NMR, ¹³C-NMR, MS, IR) of [...] Read more.

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of thecorresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene – aninteresting building-block for thiophene azo dyes – are reported. Detailed spectroscopicinvestigations (¹H-NMR, ¹³C-NMR, MS, IR) of the obtained compounds are presented. Full article

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12 KiB

Open AccessCorrection

Molecules 2002, 7, 885-895

by Derek McPhee

Molecules 2006, 11(5), 370; https://doi.org/10.3390/11050370 - 12 May 2006

Cited by 1 | Viewed by 4095

Abstract

n/a Full article

37 KiB

Open AccessCommunication

Selective Enzymatic Reduction of Aldehydes

by Guido Sello, Fulvia Orsini, Silvana Bernasconi and Patrizia Di Gennaro

Molecules 2006, 11(5), 365-369; https://doi.org/10.3390/11050365 - 12 May 2006

Cited by 11 | Viewed by 8333

Abstract

Highly selective enzymatic reductions of aldehydes to the corresponding alcohols was performed using an E. coli JM109 whole cell biocatalyst. A selective enzymatic method for the reduction of aldehydes could provide an eco-compatible alternative to chemical methods. The simplicity, fairly wide scope and [...] Read more.

Highly selective enzymatic reductions of aldehydes to the corresponding alcohols was performed using an E. coli JM109 whole cell biocatalyst. A selective enzymatic method for the reduction of aldehydes could provide an eco-compatible alternative to chemical methods. The simplicity, fairly wide scope and the very high observed chemoselectivity of this approach are its most unique features. Full article

75 KiB

Open AccessArticle

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

by Marko D. Mihovilovic, Thomas C. M. Fischer and Peter Stanetty

Molecules 2006, 11(5), 357-364; https://doi.org/10.3390/11050357 - 10 May 2006

Viewed by 8607

Abstract

We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO₂, conversion tothe corresponding acid chloride and subsequent chain elongation [...] Read more.

We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO₂, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate. Full article

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129 KiB

Open AccessArticle

An Improved NMR Study of Liposomes Using 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine as Model

by Oscar Cruciani, Luisa Mannina, Anatoli P. Sobolev, Cesare Cametti and AnnaLaura Segre

Molecules 2006, 11(5), 334-344; https://doi.org/10.3390/11050334 - 10 May 2006

Cited by 26 | Viewed by 12754

Abstract

In this paper we report a comparative characterization of Small UnilamellarVesicles (SUVs), Large Unilamellar Vesicles (LUVs) and Multilamellar Vesicles (MLVs)prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine (POPC), carried outusing two NMR techniques, namely High Resolution NMR in solution and HighResolution–Magic Angle Spinning (HR-MAS). The size and size [...] Read more.

In this paper we report a comparative characterization of Small UnilamellarVesicles (SUVs), Large Unilamellar Vesicles (LUVs) and Multilamellar Vesicles (MLVs)prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine (POPC), carried outusing two NMR techniques, namely High Resolution NMR in solution and HighResolution–Magic Angle Spinning (HR-MAS). The size and size distributions of thesevesicles were investigated using the dynamic light scattering technique. An improvedassignment of the ¹H-NMR spectrum of MLVs is also reported. Full article

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67 KiB

Open AccessArticle

Synthesis and Antitumor Evaluation of Novel Derivatives of 6-Amino-2-phenylbenzothiazoles

by Livio Racane, Ranko Stojkovic, Vesna Tralic-Kulenovic and Grace Karminski-Zamola

Molecules 2006, 11(5), 325-333; https://doi.org/10.3390/11050325 - 09 May 2006

Cited by 42 | Viewed by 8627

Abstract

Novel derivatives of 6-amino-2-phenylbenzothiazole bearing differentsubstituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as thecorresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl)benzothiazoles (1-6) weresynthesized by condensation reactions of substituted benzaldehydes with 2-amino-5-nitrothiophenol. Nitro derivatives were reduced to the amino derivatives with SnCl₂/HCl.Water [...] Read more.

Novel derivatives of 6-amino-2-phenylbenzothiazole bearing differentsubstituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as thecorresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl)benzothiazoles (1-6) weresynthesized by condensation reactions of substituted benzaldehydes with 2-amino-5-nitrothiophenol. Nitro derivatives were reduced to the amino derivatives with SnCl₂/HCl.Water soluble hydrochloride salts of 6-amino-2-(substituted-phenyl)benzothiazole (13-19)were prepared using concentrated or gaseous HCl. Compounds 13-19 were found to exertcytostatic activities against malignant human cell lines: cervical (HeLa), breast (MCF-7),colon (CaCo-2), laryngeal carcinoma (Hep-2), and normal human fibroblast cell lines (WI-38). Full article

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48 KiB

Open AccessArticle

A Handy and Solventless Direct Route to Primary 3-[3-Aryl)-1,2,4-oxadiazol-5-yl]propionamides Using Microwave Irradiation

by Ricardo A.W. Neves, Filho and Rajendra M. Srivastava

Molecules 2006, 11(5), 318-324; https://doi.org/10.3390/11050318 - 09 May 2006

Cited by 24 | Viewed by 7731

Abstract

A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described. Full article

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142 KiB

Open AccessArticle

Solvent Effects in Electrocoagulation of Selected Plant Pigments and Tannin

by Neeranuch Chairungsi, Kanlaya Jumpatong, Weerachai Phutdhawong and Duang Buddhasukh

Molecules 2006, 11(5), 309-317; https://doi.org/10.3390/11050309 - 29 Apr 2006

Cited by 6 | Viewed by 9609

Abstract

Electrocoagulation of a plant extract and certain substances representative of selected classes of plant pigments, viz. chlorophyll, a carotenoid, a phenolic substance and a tannin, was performed in ethanol containing varying amounts of water (15-75%). The results showed that the extent and efficiency [...] Read more.

Electrocoagulation of a plant extract and certain substances representative of selected classes of plant pigments, viz. chlorophyll, a carotenoid, a phenolic substance and a tannin, was performed in ethanol containing varying amounts of water (15-75%). The results showed that the extent and efficiency of coagulation of these substances tends to vary in a manner directly related to the water content of the solvent, although the tannin and the phenolic substance were less sensitive to the solvent composition and are equally well coagulated in all solvent systems studied. The findings can be applied to the removal of these substances from aqueous alcoholic plant extracts using the electrocoagulation technique. Full article

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Molecules, Volume 11, Issue 5 (May 2006) – 10 articles , Pages 309-382

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